变应性鼻炎患者和正常人群血清中重要参与因子的动态变化观察

Observation on Dynamic Change of Important Factors in Serum of Patients with Allergic Rhinitis and Normal People

目的采用组合监测方案,了解各指标在变应性鼻炎发敏过程中的动态变化;分析相互之间的调控机理,拟释放过敏性鼻炎的区域性、季节性、个体性的内在原因。方法应用放射免疫和酶联技术对变应性鼻炎患者(30例),正常对照组(20例)血样IL-4,IL-8,TNF-,αLgE水平进行检测和嗜酸性粒细胞计数。结果过敏性鼻炎患者的IL-4,IL-8,LgE水平高于正常对照组(P<0.01),并且过敏性鼻炎患者水平与正常人相比具有统计意义(P<0.01)。结论过敏性鼻炎患者多种重要参与因子有意义的变化,提示患者与正常人群测定指标(IL-4,IL-8,LgE)的明显差异,为临床诊断和预后判断提供辅助诊断的科学依据。

Objective To find out the dynamic change of several targets in the course of allergic rhinitis by the combined detection, analyze the regulative mechanism among each other and inner reasons of its regional, seasonal and individual feature. Methods By radioimmunoassay （RIA） and enzyme linked immunosorbent assay, the blood samples from the patients with allergic rhinits in onset period （ n = 30 ） and stable period （ n = 30 ） and the normal control （ n = 20 ） were detected for the level of IL - 4. IL - 8, TNF - α and IgE and the number of eosinophil. Results The levels of IL - 4, IL - 8 and IgE were higher than those of normal control （ P 〈 0.001 ）. There is statistical significance between the level in onset period and stable period （ P 〈 0.001 ）. Conclusions The sense change of the several important factors of allergic rhinitis in different periods contributes to limit whether the patients are in onset period or in stable period and affords the information for clinical diagnose, judge of prognosis and pro - show effect forecasting.