变应性鼻炎发病期和稳定期人群血清中重要参与因子的动态变化的观察

Comparison Study and Dynamic Change of Important Factors of Allergic Rhinitis in Different Periods

目的采用组合监测方案,了解各指标在变应性鼻炎发敏过程中的动态变化;分析相互之间的调控机理,拟释放过敏性鼻炎的区域性、季节性、个体性的内在原因。方法应用放射免疫和酶联技术对变应性鼻炎发病期(30例)稳定期(30例)血样IL-4,IL-8,TNF-,αLgE水平进行检测和嗜酸性粒细胞计数。结果过敏性鼻炎发病期IL-4,IL-8,IgE水平高于稳定期(P<0.01),并且过敏性鼻炎发病期测量水平与稳定期相比具有统计意义(P<0.01)。结论过敏性鼻炎患者不同时期多种重要参与因子有意义的变化,提示患者发病期与稳定期测定指标(IL-4,IL-8,LgE)的明显差异为临床诊断和预后判断提供辅助诊断的科学依据,并且依据发病期和稳定期各测量值的差异,可作为发病前预测指标。

Objective To find out the dynamic change of several targets in the course of allergic rhinitis by the combined detection, analyze the regulative mechanism among each other and inner reasons of its regional, seasonal and individual feature. Methods By radioimmunoassay （ RIA ） and enzyme linked immunosorbent assay, the blood samples from the patients with allergic rhinitis during the period of disease （ n = 30 ） and stable （ n = 30 ） and the normal controls （ n = 20 ） were detected for the level of IL - 4, IL - 8, TNF - α and IgE and the number of eosinophil. Results The levels of IL - 4, IL - 8 and IgE were higher than that of normal control （ P 〈 0. 001 ）. There were the statistical significances in the level between disease and stable groups （ P 〈 0.001 ）. Conclusions The sense change of several important factors of allergic rhinitis in different periods contributes to whether the patients are in the period of disease or stability and provides the information for clinical diagnose, judge of prognosis and pro - show effect forecasting.