摘要
以油酸聚乙二醇甘油酯为表面活性剂,制备了雷帕霉素口服液。分别采用HPLC和HPLC-MS法测定制剂中雷帕霉素的含量及有关物质。按照药典要求检查口服液的颜色和澄清度,并考察其稳定性。结果表明所制备的雷帕霉素口服液质量稳定。
Rapamicin oral solution was prepared using glycolysed ethoxylated glycerides as the anxiliary solvent. The HPLC and HPLC-MS methods were established for the determination of rapamicin and its related substances, respectively. The color and clarity as well as the stability, were examined according to the Ch E The results showed that the quality of rapamicin oral solution was satisfactory.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2006年第11期765-767,共3页
Chinese Journal of Pharmaceuticals
关键词
雷帕霉素
口服液
稳定性
测定
rapamicin
oral solution
stability
determination
