体外比较单向白蛋白透析滤过与分子吸附循环系统的血液净化作用

In vitro comparison of the purification function of single-pass albumin diafiltration (SPADF) and molecular adsorbents recirculating system (MARS)

目的体外比较单向白蛋白透析滤过(single-pass albumin diafiltration,SPADF)和分子吸附循环系统(molecular adsorbents recirculatingsystem,MARS)的血液净化作用。方法分别利用SPADF,MARS或持续性静-静脉血液透析滤过(continuous veno-venous hemodiafiltration,CVVHDF)处理含有一定浓度代谢产物的血浆,监测治疗前后血浆中胆红素,胆汁酸,氨,尿素和肌酐浓度,并利用SPSS10·0软件进行统计学分析。结果SPADF和MARS较CVVHDF可显著降低血浆胆红素水平。3种方法对水溶性代谢产物氨、尿素和肌酐的清除作用相似。结论SPADF和MARS清除血浆中白蛋白结合物质的作用相似。

Objective To compare the detoxifcation capacities of single - pass albumin diafiltration （SPADF） and molecular adsorbents recireulating system （MARS） in vitro. Methods In each experiment quantitative toxin - loaded human plasma was processed by SPADF or MARS. CWHDF （ Continuous veno - venous hemodiafiltration） was set up as control group. Levels of ammonia, urea, creatinine, bilirubin and bile acids were determined. Concentratious before and after application of detoxifcation procedures were expressed as differences and were compared using the SPSS 10.0 software. Restdts SPADF and MARS induced a more significant reduction in bilirubin levels than CWHDF. No significant differences were found among SPADF, MARS and CWHDF in removal of water soluble substances. Conclusion The detoxifcatiun capacity of SPADF and MARS is similar.