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靶控输注异丙酚复合瑞芬太尼或舒芬太尼全静脉麻醉 被引量:12

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摘要 目的 比较靶控输注异丙酚复合瑞芬太尼或舒芬太尼全静脉麻醉的血流动力学、脑电双频指数(BIS)以及术后麻醉恢复情况。方法 选择40例择期手术患者,随机分为两组。以血浆药物浓度为靶浓度,靶控输注瑞芬太尼(PR组,n=20)(3—4)μg/L或舒芬太尼(PS组,n=20)(0.4~0.6)μg/L后,逐步升高异丙酚靶浓度至BIS(45%~60%)。术中视情况调整瑞芬太尼或舒芬太尼靶浓度维持麻醉平稳,观察血流动力学、BIS值以及麻醉恢复情况。结果 麻醉诱导后两组患者收缩压(SBP)、舒张压(DBP)均降低(P〈0.05),PR组心率(HR)降低明显(P〈0.01)。气管插管、切皮及术中血流动力学稳定,PR组停药后约10rnin患者HR增快(P〈0.01)。两组患者异丙酚诱导后BIS值明显降低(P〈0.01),组间BIS值差异无显著性(P〉0.05)。停药后呼吸频率、潮气量PR组恢复迅速,PS组恢复较慢。停药至拔管时间PR组、PS组分别为(13.2±3.8)min、(29±7.5)min(P〈0,01)。结论 靶控输注异丙酚复合瑞芬太尼或舒芬太尼全静脉麻醉能达到满意的麻醉效果,瑞芬太尼或舒芬太尼浓度改变时BIS值无明显影响,复合瑞芬太尼时麻醉恢复彻底,复合舒芬太尼时麻醉恢复平稳。
出处 《广东医学》 CAS CSCD 北大核心 2006年第11期1683-1685,共3页 Guangdong Medical Journal
基金 广东省自然科学基金资助项目(编号:2002C40401) 广州市科技三项经费资助项目(编号:2005C13G0101)
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参考文献10

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二级参考文献14

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