连翘酯苷抗感染、解热作用研究

The Study of Forsythoside in Anti-infection and Abatement of Fever

本文观察了连翘酯苷的抗感染作用及解热作用,探讨其与中药连翘清热解毒作用的关系。制备小鼠三种细菌(绿脓杆菌、大肠杆菌、金黄色葡菌球菌)感染模型,观察动物的死亡数,计算死亡率；复制酵母致大鼠发热模型与内毒素致家兔发热模型,现察不同时间动物体温的变化。结果表明连翘酯苷各剂量组均可显著降低细菌感染模型动物的死亡数和死亡率；均可显著降低发热模型动物的体温。提示连翘酯苷具有明显的抗感染和解热作用。

To investigate the anti - infection and abatement of fever for Forsythoside（FOS） and its relationship with herb Forsythia suspensa. We use two feverish models （endotoxin - induced fever of rabbit, barm - induced fever of rat） to observe whether FOS has the antifebrile effect; establish thiee kinds of infection models respectively with Bacillus pyocyaneus, B. coli, staphylococcus aureus. The Result indicate body temepemture of feverish animals was lowered, and animals were protected against infection of bacterium. FOS has notable effects in anti - infection, abatement of fever and detoxication, which is worth further study.