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多肽作为非病毒转基因载体组件的研究进展 被引量：1

Development in research of polypeptides as components of nonviral gene delivery vectors
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摘要 在转基因领域,非病毒转基因载体因为具有许多病毒载体无法比拟的优点而越来越受到重视。但是理想的非病毒转基因载体的构建需要一些功能多肽的参与。这些多肽作为转基因载体的组件,在骨架构建、靶向策略的实施、内体膜的破裂和载体的核转运方面发挥重要作用。就多肽在这些方面的进展作一综述。 In the field of gene delivery, nonviral vectors are getting more attention due to the advantages which do not belong to viral vectors. But kinds of polypeptides are important to construct ideal nonviral vectors. The paper reviews the development in the research of polypeptides as components of nonviral vectors like as the backbone, the targeting moiety, the endosome membrane destabilizing agents and the nuclear localizing signals.
作者 李达 王青青 余海
机构地区 浙江大学免疫研究所
出处 《国际生物医学工程杂志》 CAS 2006年第5期307-310,共4页 International Journal of Biomedical Engineering
基金 国家高技术研究发展计划(863)资助项目(2001AA217071 2003AA216041)
关键词 多肽 非病毒载体 基因传递 polypeptides nonviral vectors gene delivery
分类号 Q78 [生物学—分子生物学]
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参考文献24

  • 1Lollo CP, Banaszczyk MG, Mullen PM, et al. Poly-L-lysine-based gene delivery systems: Synthesis, purification, and application [J].Methods Mol Med, 2002, 69:1-13.
  • 2Joubert D, van Zyl J, Hawtrey A, et al. A note on poly-L-lysine-mediated gene transfer in HeLa cells[J]. Drug Deliv, 2003, 10(3): 209-211.
  • 3Moriguchi R, Kogure K, Akita H, et al. A muhifunctional envelope-type nano device for novel gene delivery of siRNA plasmids [J ]. Int J Pharm, 2005, 301(1-2): 277-285.
  • 4Eldred SE, Pancost MR, Otte KM, et al. Effects of side chain configuration and backbone spacing on the gene delivery properties of lysine-derived cationic polymers[J]. Bioconjug Chem, 2005,16(3):694-699.
  • 5Ohsaki M, Okuda T, Wada A, et al. In vitro gene transfection using dendritic poly(L-lysine) [J]. Bioconjug Chem, 2002, 13(3): 510-517.
  • 6Meilander-Lin N J, Cheung P J, Wilson DL, et al. Sustained in vivo gene delivery from agarose hydrogel prolongs nonviral gene expression in skin[J]. Tissue Eng, 2005, 11(3-4): 546-555.
  • 7Aral C, Akbuga J. Preparation and in vitro transfection efficiency of chitosan micmspheres containing plasmid DNA: Poly(L-lysine) complexes[J]. J Pharm Pharm Sci, 2003, 6(3): 321-326.
  • 8Lee H, Jeong JH, Park TG. PEG grafted polylysine with fusogenic peptide for gene delivery: High transfection efficiency with low cytotoxicity[J]. J Contr Rel, 2002, 79(1-3): 283-291.
  • 9Ziady AG, Gedeon CR, Miller T, et al. Transfection of airway epithelium by stable PEGylated poly-L-lysine DNA nanoparticles in vivo [J]. Mol Ther, 2003, 8(6): 936-947.
  • 10Ahn CH, Chae SY, Bae YH, et al. Synthesis of biodegradable multi-block copolymers of poly (L-lysine) and poly (ethylene glycol) as a non-viral gene carrier[J ]. J Contr Rel, 2004, 97(3): 567-574.

同被引文献24

  • 1裴凌鹏,吴颖.多肽研究进展[J].首都师范大学学报（自然科学版）,2004,25(3):56-60. 被引量：15
  • 2艾国,杜丽娜,梅兴国.蛋白质、多肽类药物新剂型与新技术发展动态[J].中国生化药物杂志,2004,25(6):366-369. 被引量：9
  • 3王志超,安玉会.生物活性肽的研究进展[J].河南医学研究,2004,13(4):353-356. 被引量：29
  • 4张晟,杜建,孙蕊,熊成东,彭宇行.蛋白质、多肽类药物控制释放体系的研究[J].高分子通报,2005(1):14-19. 被引量：7
  • 5[3]Gao X,Kim KS,Liu D.Nonviral gene delivery:what we know and what is next[J].AAPS J,2007,9(1):E92-E104.
  • 6[4]Martin ME,Rice KG.Peptide-guided gene delivery[J].AAPS J,2007,9(1):E18-E19.
  • 7[5]Marshall NB,Oda SK,London CA,et al.Arginine-rich cell-penetrating peptides facilitate delivery of antisense oligomers into murine leukocytes and alter pre-mRNA splicing[J].J Immunol Methods,2007,325(1/2):114-126.
  • 8[6]Kichler A,Mason AJ,Bechinger B.Cationic amphipathic histidine-rich peptides for gene delivery[J].Biochim Biophy Acta,2006,1758(3):301-307.
  • 9[7]Morris MC,Chaloin L,Heitz F,et al.Translocating peptides and proteins and their use for gene delivery[J].Curr Opin Biotech,2000,11(5):461-466.
  • 10[9]Muratovska A,Eccles MR.Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells[J].FEBS Lett,2004,558:63-68.

引证文献1

国际生物医学工程杂志
2006年 第5期

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