137例女阴尖锐湿疣及假性显疣病理学与HPV－DNA原位杂交的研究

The pathological and hybridism in stiu trudy of condyloma acuminatum and pseudo condyloma latum

对１３７例病理学诊断为尖锐湿疣、疑似尖锐湿疣及假性湿疣的材料作地高辛村记的ＨＰＶ６Ｂ／１１ＤＮＡ原位杂交及免疫组化ＨＰＶ搞原进行检测，结果显示：尖锐湿疣中ＨＰＶ６Ｂ／１１ＤＮＡ阳性率为９９０８％（１０８／１０９），疑似尖锐湿疣中ＨＰＶ６Ｂ／１１ＤＮＡ阳性率为１１７６％（２／１７），１１例女阴假性湿疣ＨＰＶ６Ｂ／１１ＤＮＡ均增阴性。提出特征性的挖空细胞是病理学诊断尖锐湿疣的重要依据，而地高辛标记的原位杂交技术为病变的确诊提供一简便，准确的手段。

137 patients who were pathologically diagnosed with condyloma acuminatum,and with suspicious condyloma, and with pseudocondyloma latum were detected by immunohistochemistry and by DNA hybridism in situ labelled digoxin.Results showed that amomg condyloma acuminatum the positive rate of HPV6B/11DNA was 99.08%(108/109),among suspicious condyloma the positive rate was 11.76%(2/17),pseudocondylomas were negative .It indicated that pathological diagnosis mainly relied on the koilocytic cells and HPVDNA hybridization technique lablled digoxin is a simple and reliable method.