摘要
目的观察阿立哌唑治疗难治性精神分裂症的疗效及不良反应。方法48例难治性精神分裂症患者,随机分为两组,分别给予阿立哌唑与氯氮平治疗,疗程8周。采用阳性与阴性症状量表(PANSS)、副反应量表(TESS)评定疗效及不良反应。结果阿立哌唑组显效率为65.4%,氯氮平组显效率为68.2%。氯氮平药物副反应明显高于阿立哌唑组。结论对难治性精神分裂症阿立哌唑疗效与氯氮平相似,但副反应少。
Objective To explore the efficacy and side effects of aripriprazole in the treatment for refractory schizophrenia. Methods A total of 48 patients with schizophrenia were randomly divided into two groups treated with aripiprazole or elozapine respectively. The course of treatment was 8 weeks. The patients were evaluated with PANSS for efficacy and TESS for side effects. Results The effective rate of aripiprazole was 65.4% and that of elozapine was 68.2%. Clozapine was more than aripiprazole in side effects. Conclusion There is similar efficacy between ariprazole and elozapine in the treatment of refractory schizophrenia. Aripiprazole has few side effects.
出处
《山东精神医学》
2006年第4期263-265,共3页
Shangdong Archives of Psychiatry