阿立哌唑治疗难治性精神分裂症的疗效观察

The study of clinical efficacy of aripiprazole in the treatment for refractory schizophrenia

目的观察阿立哌唑治疗难治性精神分裂症的疗效及不良反应。方法48例难治性精神分裂症患者,随机分为两组,分别给予阿立哌唑与氯氮平治疗,疗程8周。采用阳性与阴性症状量表(PANSS)、副反应量表(TESS)评定疗效及不良反应。结果阿立哌唑组显效率为65．4%,氯氮平组显效率为68．2%。氯氮平药物副反应明显高于阿立哌唑组。结论对难治性精神分裂症阿立哌唑疗效与氯氮平相似,但副反应少。

Objective To explore the efficacy and side effects of aripriprazole in the treatment for refractory schizophrenia. Methods A total of 48 patients with schizophrenia were randomly divided into two groups treated with aripiprazole or elozapine respectively. The course of treatment was 8 weeks. The patients were evaluated with PANSS for efficacy and TESS for side effects. Results The effective rate of aripiprazole was 65.4% and that of elozapine was 68.2%. Clozapine was more than aripiprazole in side effects. Conclusion There is similar efficacy between ariprazole and elozapine in the treatment of refractory schizophrenia. Aripiprazole has few side effects.