可溶性CD40配体与冠脉病变的相关性研究

The Relationship of s CD40L and Coronary Artery Lesions in CHD Patients

目的:通过分析可溶性细胞表面分化抗原40配体(sCD40L)水平与冠脉病变的关系,探讨其在冠心病发病中的意义。方法:经冠脉造影确诊的冠心病患者,对冠脉病变程度进行分型,ELISA法检测血浆中sCD40L含量,分析sCD40L水平与冠脉病变程度的相关性。结果:CHD组与对照组相比,sCD40L明显增加,且随冠脉病变累计支数越多、病变越严重,sCD40L水平增高越明显。单因素相关分析显示sCD40L水平与病变支数、病变类型呈正相关关系。结论:sCD40L对ACS不稳定斑块有促进作用,通过检测其表达水平,可能对预测动脉粥样硬化的启动和进展、斑块的易损性等提供新的资料,最终可能指导治疗。

Objective： To investigate the mechanism of s CD40L in coronary heart disease （CHD） by studying the relationship between s CD40L and the severity of coronary lesions in coronary heart disease patients. Methods： 128 patients with CHD who underwent coronary angiography were investigated. Enzyme Linked lmmunosorent Assay was used to measure the level of s CD40L. The severity of coronary artery lesions was analyzed, and the lesions of coronary artery were classified. Results： s CD40L level was significantly higher in CHD patients than those in controls. The more the number of coronary. artery lesions and severity of coronary artery lesions are, the higher the level of s CD40L is, Positive correlation was seen among s CD40L level and the number of coronary artery lesions and severity of coronary artery lesions. Conclusions： s CD40L accelerated the formation of unstable plaque, It would be a valuable method to predict the priming and progresss of atherosclerotic and the vulnerability of plaque in patients by detecting the level of s CD40L.