狼疮性肾炎患者血清及尿液MCP-1测定的意义

Detection and Clinical Significance of MCP-1 in Serum and Urine of Lupus Nephritis

目的探讨狼疮性肾炎患者血清及尿液单核细胞趋化因子(MCP-1)测定的临床意义。方法采用双抗体夹心ELISA法检测血清及尿液中MCP-1水平。结果①狼疮性肾炎患者血清及尿液MCP-1水平明显高于正常对照组(P<0.01)。②病理类型越重,患者血清及尿液MCP-1水平越高,差异具有显著性。(P<0.05)。结论血清及尿液MCP-1的测定可作为狼疮性肾炎患者反映疾病活动性的指标之一。

Objective To discuss the clinical significance of MCP- 1 in lupus nephritis. Methods Adopt the method of ELISA for patients of lupus nephritis and normal control. Results （1） The level of MCP - 1 in serum and urine of lupus nephritis were significantly higher than that in normal control group （ P 〈0.01 ） （2）The level of MCP -1 in different pathology types are apparently different （ P 〈 0.05 ）. Conclusion The level of MCP - 1 in serum and urine can be an index of activity in lu- pus nephritis.