卵巢癌患者血清VEGF、CA125水平的变化及意义

Changes and significances of VEGF and CA125 in Ovary Cancer Patients

卵巢癌是女性生殖系统常见的恶性肿瘤之一，其发病率和死亡率均居各恶性肿瘤前列。其原因之一在于其不易被早期发现。晚期（Ⅲ、Ⅳ期）卵巢癌患者5年存活率仅15％～20％。利用实验室相关指标辅助诊断和动态监测卵巢癌患者病情具有重要意义。血管内皮细胞生长因子（Vascular Endothelial Growth Factor，VEGF）是肿瘤血管生成过程中作用最强，特异性最高的促血管生长因子．而CA125作为一种肿瘤标记物已被广泛用于妇科肿瘤的监测中。本文报道不同分期及术后一年随访卵巢癌患者血清VEGF和CA125水平的变化，为临床正确诊断和治疗监测提供实验室依据。

Objective: To observe the level of VEGF and CA125 and discuss their changes and clinical significances in ovary cancer patients.Method: By using ELISA and MEIA,examine VEGF and CA125 in 31 benign ovary tumor patients,64 ovary cancer patients and 44 healthy female.And inspect VEGF and CA125 of 26 ovary cancer patients after operation.Results: VEGF and CA125 of ovary cancer patients were obviously higher than that of benign ovary tumor and normal control group(P<0.01),the terminal (3~ rd and 4~ th periods) ovary cancer patients were obviously higher than the forepart (1~ st and 2~ nd periods) (P<0.01).VEGF and CA125 of 26 ovary cancer patients after operation were obviously reduced.Conclusion: There is a close connection between VEGF,CA125 and ovary cancer incidence.It is of great significance to examine VEGF and CA125 to judge and diagnose ovary cancer and determine its malignant degree and estimate prognosis.