摘要
目的:对两面针根的化学成分进行分离和鉴定。方法:采用硅胶柱色谱、Sephadex LH-20柱色谱及重结晶等方法进行成分分离及精制,并利用^1H-NMR,^13C-NMR,MS等光谱技术鉴定其化学结构。结果:从两面针根乙醇提取液的氯仿部分和正丁醇部分分离得到10个单体化合物,分别鉴定为2,4-二羟基嘧啶(2,4-dihydroxypyrimidine,1),紫丁香酸(syringicacid,2),2,6-二甲氧基对苯醌(2,6-dimethoxy-1,4-benzoquinone,3),对羟基苯甲酸(4-hydroxybenzoic acid,4),对羟基苯甲酸乙酯(ethylparaben,5),顺-3-(2,3,4-三甲氧基苯基)丙烯酸[(Z)-3-(2,3,4.trimethoxyphenyl)acrylica cid,6],5,6,7-三甲氧基香豆素(5,6,7-trimethoxycoumarin,7),stigmast-9(11)-en-3-ol(8).胡萝卜苷(9),β-谷甾醇(10)。结论:化合物1—9为首次从两面针中分离得到,化合物6是新天然产物。
Objective: To study the chemical constituents of Zanthoxylum nitidum. Method: Column chromatography on Silica gel and Sephadex LH -20, and recrystallization were applied for the isolation and purification of the constituents, The structures were elucidated on the basis of spectral analysis, chemical evidences and by comparison with the data reported in literature. Result: From the CHCl3 fraction and n-butanol fraction of the EtOH extract of the roots ofZ. nitidum, 10 compounds were isolated and identified as 2, 4-dihydroxypyrimidine (1), syringic acid (2), 2, 6-dimethoxy-1, 4-benzoquinone (3), 4-hydroxybenzoic acid (4), ethylparaben (5) , (Z) -3- ( 2, 3, 4-trimethoxyphenyl) acrylic acid (6) , 5, 6, 7-trimethoxycoumarin (7) , stigmast-9 ( 11 ) -en-3-ol (8) , daucosterol (9), β-sitosterol (10). Conclusion: Compounds 1-9 were isolated and identified from the roots of Z. nitidum for the first time. Furthermore, we note here the first isolation of compound 6 as a natural product.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2006年第20期1689-1691,共3页
China Journal of Chinese Materia Medica
基金
上海市科技发展基金(04DZ19842)
关键词
两面针
芸香科
化学成分
Zanthoxylum nitidum
Rutaceae
chemical constituent