外周血白细胞与代谢综合征的相关性研究

Correlation between peripheral white blood cell count and metabolic syndrome

目的探讨外周血白细胞(WBC)与代谢综合征的相关性。方法分析了336例门诊体检人员的吸烟、饮酒情况及代谢综合征的多项指标如腹围、体重指数、血压、血糖、血脂、尿酸水平与WBC的相关性。结果(1)代谢综合征组外周血WBC为(7.2±1.7)×109/L,明显高于非代谢综合征组的(6.5±1.6)×109/L。(2)吸烟、饮酒、腹围、体重指数、空腹血糖、收缩压、舒张压、低密度脂蛋白-胆固醇、甘油三酯、尿酸水平与WBC呈正相关,而高密度脂蛋白-胆固醇与之呈负相关。(3)WBC随着人群所含代谢综合征的组成成分个数的增多而上升。结论WBC与代谢综合征的多种组成成分具有明显的相关性。WBC不同程度的增高可以作为慢性亚临床炎症反应的表现,并能促进代谢综合征的发生与发展。

Objective To examine the correlation of peripheral white blood cell （WBC） count and the metabolic syndrome （MS）. Method The correlation between smoking, drinking, waist circumference （WC） , body mass index （BMI）, blood pressures （Bp）, blood lipids,fasting blood glucose （ FBG）, uric acid （UA） and WBC count were analyzed. The differences of each variable between different groups according to the quartiles of WBC count and also according to the number of components of the MS were analyzed. Results （1） The WBC count in MS group was significantly higher than that in non -MS group. （2）There was strong correlation between WBC count and WC, BMI, SBP, DBP, TG, HDL - C, LDL - C, FBG, UA. （3） Compared to the subjects with no component of MS, the WBC increments in subjects grouped according to the presence of 1,2,3 and ≥ 4 components of the MS increased accordingly. Conclusion There is significant correlation between peripheral WBC count and the MS. The increased WBC count may be one feature of chronic subclinical inflammation and makes contribution to the development of MS.