慢性阻塞性肺病患者深吸气量和生活质量的相关性研究

Correlation of inspiratory capacity and the quality of life in patients with chronic obstructive pulmonary disease

目的探讨深吸气量(IC)和慢性阻塞性肺病(COPD)患者生活质量的相关性。方法对65例COPD稳定期患者(Ⅱ、Ⅲ期)进行肺功能检查、StGeorge呼吸问卷(SGRQ)评分以及患者日记,并对结果进行多元相关性分析。结果SGRQ呼吸症状、活动受限、疾病影响三个能区分值与总分之间具有很好的相关性(相关系数分别为0.887、0.944和0.970,P<0.01),并且四者与患者症状积分间也有很好的相关性(相关系数分别为0.861、0.769、0.773和0.835,P<0.01)。第1秒钟用力呼气量(FEV1)占预计值百分比、肺总量(TLC)占预计值百分比、残气量(RV)占预计值百分比、IC占预计值百分比与SGRQ各能区分值及总分间具有相关性(P<0.05)。与FEV1占预计值百分比相比,IC占预计值百分比与SGRQ评分具有更高的相关性。结论肺功能检查结果与COPD患者的生活质量相关,与FEV1占预计值百分比相比,IC占预计值百分比对COPD患者的实际生活质量评价具有更高的价值,应当在临床上得到重视。

Objective To study the correlation of inspiratory capacity（IC） and the quality of llfe in patients with chronic obstructive pulmonary disease（ COPD ）. Methods The st George respiratory questionnaire（SGRQ） score, patient diary and spirometry were collected from 65 stable patients with COPD （ stage Ⅱ,Ⅲ ）. The validity was documented by performing correlation analysis, and Pearson＇ s correlation coefficients were calculated. Result The correlation coefficients between the total score and the other three section scores of SGRQ were 0. 887, 0. 944 and 0. 970, respectively ,P 〈 0.01. The four SGRQ section scores were significantly correlated with the patient＇s symptom integral respectively （0. 861,0.769, 0.773 and 0. 835 ,P 〈0.01 ）. Also the SGRQ score were significantly correlated with forced expiratory volume in one second （FEV1） pred, total lung capacity （TLC）pred, residual volume （RV） pred and inspiratory capacity （IC） pred （ P 〈 0.05 ）. Compared with FEV1% pred, IC% pred was better correlation with the SGRQ score. Conclusion The spirometry results correlate with the quality of life in patients with COPD. Compared with FEV1, IC is a better index to evaluate the quality of life in patients with COPD.