后腹膜腔人工CO_2气腹对兔肝、肾功能的影响

Influence of CO_2 pneumoperitoneum on rabbit hepatic and renal function during retroperitoneoscopy

目的探讨后腹膜腔人工CO2气腹对兔肝、肾功能的影响。方法新西兰白兔20只,随机分为2kPa1h组、2kPa2h组、4kPa1h组、4kPa2h组;建立后腹膜腔后应用气腹机自动完成气腹。测定气腹前、气腹后1、3、5d肝、肾功能,应用统计学方法分析指标动态变化规律。结果气腹后1d可出现不同程度的肝、肾功能减退,气腹后3d开始好转,第5天恢复至气腹前水平,这种改变与气腹压力、气腹持续时间相关。结论后腹膜腔人工CO2气腹可以引起肝、肾功能改变,后腹腔镜手术应注意气腹压力和持续时间。

Objective To study the effect of artificial carbon dioxide（CO2） pneumoperitoneum on hepatic and renal function during retroperitoneoscopy. Methods 20 rabbits were divided into four groups： 2 kPa 1 h, 2 kPa 2 h, 4 kPa 1 h and 4 kPa 2 h. After retroperitoneoscopy was established, carbon dioxide pneumoperitoneum was made automatically. The hepatic function（ALT, AST, TBIL） and renal function（BUN, CR） were measured before the establishment of pneumoperitoneum, one day, three days and five days after that. Results After the establishment of pneumoperitoneum, the hepatic function and renal function declined, but all the parameters resumed to the usual level five days later. The changes were related to the pressure and duration of carbon dioxide pneumoperitoneum. Gonclusion CO2pneumoperitoneum during retroperitoneoscopy has obvious effect on hepatic and renal function, so more attention should be paid to the pressure and duration of carbon dioxide pneumoperitoneum.