脂毒性心肌病的研究进展

Advances in Research of Lipotoxic Cardiomyopathy

心脏中脂质大量积聚,可以引起心脏功能异常,称之为脂毒性心肌病。目前,脂毒性心肌病已在大量的转基因小鼠模型中发现,证明了有心脏毒性的脂质积聚与脂毒性心肌病是相关联的。研究过氧化物酶体增殖剂活化受体在脂毒性心肌病中的作用,可以为预防和治疗脂毒性心肌病提供新思路。

Lipid accumulation in the heart may lead to cardiac dysfunction, which is called lipotoxic cardiomyopathy. At present, lipotoxic cardiomyopathy has been found in numerous transgenic mouse models, and proves that the accumulation of cardiotoxic lipid species is associated with lipotoxic cardiomyopathy. Studies of the role of the peroxisome proliferators-activated receptor plays in lipotoxic cardiomyopathy will provide new strategies to prevent and cure lipotoxic cardiomyopathy.