阿司匹林抵抗研究存在的问题与展望

A Study of Aspirin Resistance

阿司匹林是心血管疾病治疗的关键用药之一。虽然它能有效的抗血小板聚集,但是有些患者经过长期随访仍有心血管事件发生,称为阿司匹林抵抗。阿司匹林抵抗的机制不明确,而且缺乏快速的、临床实用的、准确的检测方法。通过进一步研究阿司匹林抵抗的机制和临床特征,我们应该象监测胆固醇、血压、血糖一样,监测血小板活性而指导患者进行个体化的抗血小板治疗,从而提高此类患者的治疗效果。

Aspirin has emerged as an important element of the treatment of cardiovascular disease. Despite its efficacy, patients on these medications continue to suffer complications. Aspirin resistance is an emerging clinical entity with potentially severe consequences. The mechanism of resistance remains incompletely defined. Rapid and accurate diagnosis of antiplatelet resistance also remains an issue as new bedside tests are developed. By understanding the mechanism of therapeutic failure and by improving the diagnosis of this clinical entity, a new era of individualized antiplatelet therapy may come about, with routine measurements of platelet activity, in the same way that cholester- ol, blood pressure, and blood sugar are monitored, thus improving care for millions of people.