炎症因子与冠心病合并糖尿病关系的研究进展

Advances in Research into the Relationship Between Inflammatory Factor and Coronary Heart Disease in Patients with Type 2 Diabetes

冠心病和糖尿病存在胰岛素抵抗、慢性炎症反应的共同土壤,均是一种炎症性疾病,炎症因子C反应蛋白(CRP)和纤溶酶原激活物抑制物-1(PAI-1)在动脉粥样硬化性疾病及2型糖尿病的发生、发展过程中起着重要的作用,冠心病合并糖尿病患者体内的炎症因子CRP、PAI-1水平较单纯冠心病、糖尿病均高,增高的CRP、PAI-1具有潜在的预测不稳定斑块破裂血栓形成发生急性心血管事件的作用,同时增高的CRP、PAI-1对2型糖尿病发病情况也起重要预测作用。并且为早期干预、指导治疗提供一定理论依据。

Coronary heart disease and type 2 diabetes both involve insulin resistance and chronic inflammatory reaction, Both are inflammatory diseases. C-reaction protein （CRP） and plasminogen activator inhibitor type 1 （PAI-1） play an important role in the developmental progress of atherosclerosis and type 2 diabetes, Inflammatory factor CRP and PAI-1 in patients with coronary heart disease with type 2 diabetes are higher than those who are have either coronary heart disease or type 2 diabetes. The elevated levels of CRPand PAI-1 can potentially predict unstable plaque rupture, thrombosis and acute heart events. They can also predict the incidence of type 2 diabetes. Furthermore, elevated levels of CRP and PAI-1 may provide theoretical evidence of the need for early stage interventional and other therapies.