硒酵母抗癌活性研究

Anticancer Activity of Selenium Yeast

目的研究不同浓度硒酵母对肿瘤细胞的抑制作用。方法体外培养宫颈癌细胞,经不同浓度的硒酵母处理,MTT法测定硒酵母对肿瘤细胞的抑制作用。小鼠体内接种腹水型肝癌细胞H22,观察硒酵母体内抗肿瘤作用。测量小鼠体重变化,CD4+,CD8+含量,白蛋白、总蛋白含量。结果含硒5μg/m l的硒酵母即能显著抑制荷癌小鼠腹水生成,提高CD4+,CD8+比值,升高血清白蛋白及总蛋白含量(P<0.01)。结论硒酵母具有良好的抗肿瘤作用,其作用优于同剂量的亚硒酸钠。

Objective To study the anticancer activity of different density selenium yeast. Methods Cultured cancer cells of cervix in vitro,treated by different density selenium yeast, used the way of MTT to determine the activity of inhibition against the tumour cell.. Inoculated hepatoma cell H22 to mouse abdominal cavity , observed the anticancer activity of selenium yeast in vivo, Measured the changes of body weight , content of CD4^＋ , CD8^＋, protein level of albumin and total protein. Results The experiment showed that selenium yeast（ containing selenium 5μg/ml） significant inhibited the formation of cervix cancer in vitro（P 〈 0.05 ）, selenium yeast （containing selenium 15 μg/ml） decreased abdominal dropsy , heightened the ratio of CD4^＋/CD8^＋ , increased protein level of albumin and total protein （ P 〈 0.01 ）. Conclusion Selenium yeast have favourable anticancer activity. It is better than Sodium selenite with the same dose.