血小板和组织因子

Platelet and tissue Factor——Review

组织因子(tissue factor,TF)在凝血和血管内血栓形成中起重要作用,它不仅存在于血管外组织细胞中,而且也存在于血循环细胞中。血中单核细胞可以被内毒素等诱导表达组织因子。近年来许多研究证明,血小板上的P-选择蛋白、CD40配体及GPⅡb/Ⅲa受体等也影响单核细胞表达组织因子。除此之外,有相当多的证据表明,在生理情况下,血循环中也存在组织因子,血小板内的组织因子是其中一部分,它在一定的条件下释放,启动凝血反应。本文就参与凝血的血小板和组织因子的关系作一综述性分析。

It is generally accepted that tissue factor plays an important role in coagulation and intravascular thrombus formation. Tissue factor is not only found primarily on the surface of certain cells that are located outside the vasculature, but also found in circulating cells. Monocyte express tissue factor induced by endotoxin. Recently, many researches indicate that P-selectin, CD40 ligand and GP Ⅱ b/Ⅲa receptor of platelet can also affect expression of tissue factor by monocyters. In addition, a lot of studies showed that tissue factor exist in the circulation including contained platelet. Tissue factor in the platelet releases under certain condition, and initiates coagulation. In this review the relation between platelet and tissue factor was elaborated.