糖尿病大鼠腹腔内移植微囊化成猪胰岛疗效观察

Observation of Intraperitoneal Transplantation of Encapsulated Adult Pig Pancreatic Islets into Experimental Diabetic Rat

18只链脲佐菌素制备的糖尿病模型大鼠随机分为三组：对照组、本微囊化胰岛移植组和微囊化胰岛移植组。移植物由成猪胰腺制备。移植量均为1克。结果：移植前三组血糖水平无显著差异；移植7天后，三组的血糖分别为22．67±1．15mmol／L，18．58±2．62mmol／L和14．87±2．40mmol／L。微囊化胰岛移植组与前两组比较均有显著差异，且生存期明显长于前两组，表明微囊化成猪胰岛可存活于糖尿病大鼠体内，并具有生物活性。

The diabetic rats induced by streptozotocin were separated into three groups: control group, unencapsulated pancreatic islets transplantation group and encapsulated pancreatic islets transplantation group.Xenografts were prepared by adult pig pancreas. Result: there was no signilicant difference in the mean levels of the blood glucose before transplantation among the three groups. On the 7th day after transplantation, the mean levels of the blood glucose in the three groups were 22. 76±1. 15mmol/L, 18. 58± 2. 62mmol/L and 14. 87 ±2. 40mmol/L, respectively. There is significant difference between encapsulated pancreatic islets transplantation group as compared with the other two groups (P＜0. 01,P＜0. 05 resPectively). The result suggests that microencapsulated adult pig pancreatic islets may survive in diabetic rats with their biological activity.