南宁地区五年淋病奈瑟菌耐药监测研究

Study on antibiotic resistance of Neisseria gonorrhoeae in Nanning for 5 years

目的监测南宁地区淋病奈瑟菌对抗菌药物的耐药性及产青霉素酶淋病奈瑟菌(PPNG)和高水平耐四环素淋病奈瑟菌(TRNG)的流行情况。方法用琼脂稀释法测定最低抑菌浓度(MIC)及纸片酸度法测定β内酰胺酶。结果在检测的458株淋病奈瑟菌中检出PPNG阳性33株(7·20%),TRNG阳性231株(50·44%),对环丙沙星、头孢曲松和大观霉素的耐药率分别为87·33%,1·31%和0·22%。结论南宁地区淋病奈瑟菌对环丙沙星的耐药最严重,也出现了个别耐头孢曲松和耐大观霉素的淋病奈瑟菌菌株,说明持续对淋病奈瑟菌的耐药监测十分重要。

Objective To study the antibiotic resistance of Neisseria gonorrhoeae and the prevalence of penicillinase-producing Neisseria gonorrhoeae （PPNG） and high-level tetracycline resistant Neisseria gonorrhoeae （TRNG） in Nanning. Methods Minimum inhibitory concentrations （MIC） were determined by agar dilution method and β-lactamase production was comfirmed by acidometric method. Results Among 458 strains, 33 strains （7. 20% ） were found to be PPNG and 231 strains （50. 44% ） were TRNG. The resistance rate to ciprofloxacin, ceftriaxone and spectinomycin were 87. 33%, 1.31% and 0. 22% respectively. Condusion The situation of resistance to ciprofloxacin was very serious, and it was also found that a few of gonococcal isolates were resistant to ceftriaxone and spectinomycin. The study showed that it is important to successively survey the antibiotic resistance of Neisseria gonorrhoeae.