人乳头状瘤病毒感染与尖锐湿疣及宫颈癌的比较研究

Comparison of human papillom virus DNA in condylomata acuminata,cervical cancer and female genital tract

目的探讨不同种类人乳头状瘤病毒(HPV)感染与病变性质的关系。方法采用基因芯片技术,对195例患者宫颈分泌物中的HPVDNA分别进行检测。其中,尖锐湿疣62例,宫颈癌48例和正常对照85例,并对HPV感染的主要类型进行分析。结果上述宫颈分泌物中的HPV的检出率分别为96.77%、97.92%和22.35%。宫颈各病变组中HPV的检出率显著高于对照组(P<0.001)。尖锐湿疣组中低危型HPV的检出率为61.29%,宫颈癌组中高危型HPV检出率为77.08%,两者HPV型别分布差异有显著意义(P<0.001)。结论尖锐湿疣和宫颈癌的发生与HPV感染高度相关。尖锐湿疣常与低危型HPV感染有关;宫颈癌的发生则与高危型HPV关系密切。

[Objective] To investigate the relationship between human papilloma virus （HPV） infection and several lesions of the genital traet. [Methods] HPV DNA expression in seeretion of eondylomata aeuminata（CA）, eervieal eaneer and normal eervieal was deteeted by gene ehip teehnique. Main HPV typos were eompared in CA and eervical cancer. [Results] The total positive rate of HPV in the secretion of CA, cervical cancer and normal cervical were 96.77%（60/62）, 97.92%（47148） and 22.35%（19/85）, respoetively. Those of the cervieal lesions were signifieantly higher than that of the normal eontrols （P 〈0.001）. The predominant HPV typos in CA group were the low-risk typos HPV （61.29%）, while the high-risk types HPV were more frequently found in the cervical cancer group （77.08%）. The differenee of distribution of HPV types in CA and eervieal eaneer was statistieally signifieant （P 〈0.001）. [Conclusion] HPV infeetions are intimately linked to CA and eervieal eaneer. The low-risk typos HPV seem to be associated with CA; the high-risk types are closely related to cervical cancer.