E-钙黏蛋白和nm23-H1在肝细胞性肝癌中的表达及其临床意义

Expression and clinical significance of E-cadherin and nm23-H1 in hepatocellular carcinoma

目的探讨E-钙黏蛋白(E-cadherin)和nm23-H1在肝细胞性肝癌(HCC)中的表达及其与肝癌浸润转移之间的关系。方法应用免疫组化S-P技术,检测50例肝癌组织中E-cadherin和nm23-H1的表达,分析与肝癌侵袭转移之间的关系。结果50例肝癌组织中E-cadherin和nm23-H1的表达与HCC的Edmondson分级、侵袭转移能力密切相关,而与患者性别、年龄、肿瘤大小无关。E-cadherin和nm23-H1的表达具有高度协同性。结论E-cadherin和nm23-H1的表达能反映HCC的侵袭转移能力。联合检测两种蛋白在肿瘤组织中的表达,可以更准确判断HCC的恶性程度和生物学行为。

Objective To explore the expressions of E cadherin and nm23-H1 in hepatocellular carcinoma （HCC） their relationship with invasion and metastasis of HCC. Methods Immunohistochemical S-P technique was used to detect the expressions of E-cadherin and nm23i-H1 in primary tumor tissues from 50 cases with HCC and analyze their relationship with invasion and metastasis of HCC. Results In 50 cases, the expressions of E-cadherin and nm23-H1 in HCC closely related with Edmondson grade and metastasis potential of HCC but had none correlation with size of tumor, sex and age of cases, with high cooperative ness upon expressions of E-cadherin and nm23-H1. Conclusions Expressions of E-cadherin and nm23-H1 may reflect potential of invasion and metastasis of HCC. Furthermore, combined detection of expressions of E-cadherin and nm23-H1 in tissues of HCC may more accurately judge the malignancy degree and biological behavior of HCC.