摘要
合成了羟甲基磺酸钠，并对7-氨基-4-萘酚-2-磺酸的磺甲基化反应进行了研究。通过正交试验和单因素实验，确定了7-氨基-4-萘酚-2-磺酸磺甲基化反应的较佳工艺条件为：7-氨基-4-萘酚-2-磺酸与羟甲基磺酸钠摩尔比为1：1．15，pH6．0～6．5，温度40℃，时间3h。产品收率可达96％，HPLC分析纯度达95％以上。产品的结构通过红外、质谱、核磁共振氢谱等进行了鉴定。
Sodium hydroxymethanesulfonate was synthesized and the sulfomethylation of 7-amino-4-hydroxynaphthalene-2-sulfonic acid was studied. The optimum conditions of sulfomethylation were n （7-amino-4-hydroxynaphthalene-2-sulfonic acid） ： n （ sodium hydroxymethanesulfonate）=1： 1.15, pH=6.0～6.5, reaction temperature 40 ℃ and reaction time 3 h. The yield of the product was 96%, and its purity was over 95% by HPLC. The product was characterized by IR, MS and ^1H NMR.
出处
《青岛科技大学学报（自然科学版）》
CAS
2006年第5期380-382,387,共4页
Journal of Qingdao University of Science and Technology:Natural Science Edition
关键词
7-氨基-4-萘酚-2-磺酸
羟甲基磺酸钠
磺甲基化
7-amino-4-hydroxynaphthalene-2-sulfonic acid
sodium hydroxymethanesulfonate
sulfomethylation
