836例乳腺癌雌孕激素受体表达的临床分析

Clinical Analysis on Expression of Estrogen and Progesterone Receptors in Breast Cancer (A Report of 836 Cases)

目的:探讨乳腺癌患者雌、孕激素受体状态分布及与临床指标的关系。方法:采用SP二步法对836例乳腺癌患者的术后肿瘤石蜡标本进行雌、孕激素受体检测,并与患者的年龄、月经情况、原发肿瘤病理类型和腋淋巴结转移状况相结合进行分析。结果:ER和PR的表达呈显著正相关(P<0.001);ER(+)、PR(+)、PR(-)表达率和年龄分布无关(P>0.05),≤39岁年龄组ER(-)表达率明显高于其他年龄组(P<0.001);绝经后ER(+)率高于绝经前患者(P<0.001),PR(+)率低于绝经前患者(P<0.001);组织病理学类型和ER、PR之间关系无显著性差异(P>0.05);无腋淋巴结转移患者的ER(+)、PR(+)表达率显著高于有转移者(P<0.001),ER(-)、PR(-)表达率低于有腋淋巴结转移者(P<0.001)。结论:乳腺癌患者ER、PR表达有一定规律,可作为制定综合治疗方案的依据,同时对判断预后有一定意义。

Objective： To explore the distribution of estrogen receptor （ER） and progesterone receptor （PR） in breast cancer patients and compare the relationship between ER, PR and clinical parameters. Methods： 836 specimens of breast cancer were stained for ER and PR by SP two step method, and compared with age, menstuation status, histopathology and metastases of axillary lymph nodes in breast cancer patients. Results： The correlation between ER and PR was positive （P〈0.001）. The expression of ER（＋） ,PR（＋） and PR（-） were not associated with the age of patients （P〉0.05）. The ER negative expression in patients aged 39 or younger was significantly higher than other age groups （P〈0.001）. The ER（＋） expression in postmenopausal patients were higher than that of the premenopausal ones （P〈0.001）, while the PR（＋） expression was lower than that of the premenopausal patients （P〈0.001）. There was no significant difference between the histopathological type and the expression of ER and PR （P〉0.05）. The expression of ER（＋） and PR（＋） in patients without axillary lymph node metastasis were significantly higher than those in positive axillary lymph nodes ones （P〈0.001）, whereas the expression of ER（-） and PR（-） in patients without axillary lymphatic metastasis were lower than those in positive patients （P〈0.001）. Conclusion： The expression of ER and PR has certain regular patterns and may be as the marker to select the combining therapy and estimate the prognosis in breast cancer patients.