C反应蛋白检测在监测慢性阻塞性肺疾病急性加重期使用糖皮质激素治疗临床研究

Clinical Study of C-reaction Protein Examination in Detecting Glucocorticoids Therapy for COPDAE Patients

目的:探讨CRP(C反应蛋白)检测在监测COPD(慢性阻塞性肺疾病)急性加重期使用糖皮质激素治疗中炎症控制的临床应用价值。方法:使用糖皮质激素及未使用糖皮质激素治疗细菌感染引起COPD急性加重期患者,记录治疗前后血白细胞(WBC)、CRP浓度、血沉。结果:使用激素及未使用激素治疗前后的WBC、CRP浓度、血沉有显著性差异(P<0.05),但使用激素治疗后WBC是升高的。结论:CRP可作为观察COPD急性加重期使用糖皮质激素治疗中炎症控制的敏感指标。

Objective： To study the clinical application value of CRP examination in detecting inflammation of COPDAE patients treated by glucocorticoids. Methods： COPDAE patients infected by germ were treated by glucocorticoids and nonglucocorticoids. The data of CRP、ESR and WBC were made before and after these therapies. Results： Before and after these therapies, the differences of the data of CRP, ESR and WBC were significant （P〈0.05）, but the number of WBC was increased after glucocorticoids therapy. Conclusion： The CRP is a sensitive index in detecting imflammation of COPDAE patients treated by glucocorticoids.