谷氨酰胺与重组人生长激素对肝硬化患者外周血淋巴细胞及白细胞的影响

Effects of glutamine and recombinant human growth hormone on peripheral leukocytes and lymphocytes in cirrhotic patients

目的:探讨谷氨酰胺(Gln)与重组人生长激素(rhGh)各自应用及联合应用对肝硬化患者外周血淋巴细胞、白细胞计数的影响。方法:选取20例肝硬化患者,随机分成4组,所有患者给予等氮等热量营养支持7d,Gln+rhGh组口服Gln犤0.3g/(kg·d)犦和皮下注射rhGh(10U/d),Gln组口服Gln,rhGh组皮下注射rhGh,肝硬化对照组给予相应安慰剂。观察治疗前后患者白细胞、淋巴细胞计数以及淋巴细胞百分比的变化,并分别进行比较。结果:Gln+rhGh组治疗后,淋巴细胞计数以及淋巴细胞百分比都有显著意义的升高,与其他3组比较差异有统计学意义(P<0.05),而各组白细胞总数无显著意义的变化。结论:Gln与rhGh联合应用能提高淋巴细胞计数以及淋巴细胞百分比。

Objective To investigate the effects of glutamine （Gin） alone or in combination with recombinant human growth hormone （rhGh）, or rhGh alone on the peripheral leukocyte and lymphocyte count in cirrhotic patients. Methods Twenty patients were randomly assigned to receive oral Gin [0.3 g/（kg· d）] and rhGh （10 U/d） subcutaneously, Gin alone, rhGh alone, or placebo（control） . All of the patients were restricted with isocaloric and isonitrogenic nutritional intake for 7 consecutive days. Changes in leukocyte count, lymphocyte count and percentage were investigated after the trial and comparison was made among groups. Results The lymphocyte count and percentage were significandy higher in Gin ＋ rhGh group compared with those in the other 3 groups（ P 〈 0. 05）. No marked changes in total leukocyte count occurred in any one group. Conclusion The Gin combined with rhGh therapy for cirrhotic patients can enhance the peripheral lymphocyte count and percentage.