摘要
目的:观察10-羟基-2-癸烯酸(10-HDA)对荷瘤小鼠的抑瘤作用及免疫功能的影响。方法:接种S180小鼠的瘤重、接种艾氏腹水癌小鼠的生存期及因荷瘤而降低的迟发型超敏反应为指标,观察腹腔注射10-HDA的作用。结果:10-HDA明显抑制S180实体瘤生长,延长艾氏腹水癌小鼠生存期,并能恢复小鼠因荷瘤而降低的迟发型超敏反应。结论:腹腔注射10-HDA对小鼠S180实体瘤及艾氏腹水癌具有抑瘤作用,并能恢复因荷瘤所致的免疫功能低下,后者可能与其体内抗肿瘤作用有关。
Objective:The effect of 10-Hydroxy-2-decenoic acid(10-HDA),unsaturated fatty acid ex-tracted from royal jelly,on tumor and immune function was studied in tumor-bearing mice,Methods:The effect of 10-HDA ip on the weight of tumor,survival time and delayed type hypersensitivity(DTH)was observed in S180 or EVC bearing mice. Results:10-HDA significantly decreased tumor weight in S180-bearing mice,prolonged the survival time in EAC-bearing mice and restored the de-creased DTH in both kinds of tumor bearing mice. Conclusion:These results indicate that 10-HDA ip had antitumor and immunopotentiating effects,the latter may involve the antitumor activity of 10-HDA
出处
《北京医科大学学报》
CSCD
1996年第5期331-333,共3页
Journal of Peking University(Health Sciences)
关键词
癸烯酸
药物疗法
药理学
肿瘤
Hydroxy-2-decenoic acid/pharmacol
Sarcoma 180/drug ther
Carcinoma/Ehrlich tu-mor
Hypersensitivity,delayed/durg ther