湖北地区三级医院2002～2005年克雷伯菌属耐药性变迁分析

Analysis of antibiotic resistant changing in Klebsiella pneumonia in the third grade hospitals of Hubei province.

目的 调查湖北地区克雷伯菌属的耐药性及流行趋势，为，临床提供诊疗依据。方法 采用WHO NET4-5软件对3992株克雷伯菌属菌株的耐药率进行统计分析。菌株分离自湖北地区17所三级医院2002～2005年成人患者各类临床标本。结果 4年中湖北地区克雷伯菌属对常用抗菌药物的耐药率基本持平或略有上升，对氨苄西林耐药率高达98％～99％；对亚胺培南100％敏感。产超广谱G内酰胺酶（ESBLs）菌株的检出率呈上升趋势，由27．2％上升到35．4％。结论4年来湖北地区克雷伯菌属的耐药率基本持平，说明坚持细菌耐药性监测与公示，合理使用抗生素，对控制耐药菌的传播与流行是有效的。

Objective To explore antibiotic resistance in KlebsieUa pneumonia and the epidemiological character of these strains. Provide available antibiotic selecting methods for the clinical treatment. Methods Provide statistic analysis to the antibiotic resistant ratio in 3992 isolates of Klebsiella pneumonia by WHO NET4 - 5 software. The strains were recovered from all kinds of clinical specimens of adult patients in 17 3rd grade hospitals in Hubei province. Results In the four years,the resistance to antibiotics in Klebsiella pneumonia was on slight rise;the resistance to ampieillin was 98% - 99% ;all of these strains wrer susceptible to imipenem.The ratio of ESBLs in this period increased from 27.2% to 35.4% .Conclusion Antibiotic resistance of Klebsiella pneumonia in Hubei province was not on rise. It is efficient to control the occurrence and spread of the drug resistant bacteria by monitoring antibiotic resistance and using antibiotics appropriately.