新型硬化剂的动物实验与临床应用

NEW SCLEROSING AGENT:THE RESULT OF ANIMAL EXPERIMENT AND CLINICAL USE

目的：寻找更有效的硬化剂治疗食管静脉曲张破裂出血。方法：配制一种新型硬化剂，其成分为１．５％孟氏液７０ｍｌ、２０％利多卡因２０ｍｌ、红霉素０．５ｇ及注射用水１０ｍｌ，将这种硬化剂注射到兔耳的血管内，还应用于９例肝硬化食管静脉曲张破裂出血病人，并设对照组。结果：新型硬化剂局部止血比５％鱼肝油酸钠和消痔灵的效果好，临床止血效果与１％乙氧硬化醇相同，且对动物肝、肾无损害。结论：新型硬化剂具有安全、有效、副作用小而价廉的优点。

Objective:More effective agent to treat the patients with looking for esophageal variceal bleeding. Methods:We made a new sclerosing agent consisting of 15%Monsel′s solution 70 ml,20% lidocaine 20 ml,erythromycin 0.5 g and water 10 ml.In animal experiment,We used it as a sclerosing agent and injected it into the blood vessels of the ear of the rahhits.The new sclerosing agent was also used in 9 patients suffering from bleeding of varicosis of liver cirrhosis. Results: We found that the new sclerosing agent had a better effect on local blood coagulation than that of 5% sodium morrhuate or Xi-aozhiling,It had no harmful effect on liver and kidney functions Also,it doesn′t influence the PTA.The effect of blood coagulation is the same as that of 1% aethoxyscklerol.However,it is much cheaper with only one percent of the latter′s price.Conclusion:The new sclerosing agent is a safe effective and cheape agent,with few side effects.