高原地区子癎前期患者分娩前后血浆降钙素基因相关肽及内皮素水平的变化

The Change of Calcitonin Gene-related Peptide and Endothelin in Peripartum of Patients with Preeclampsia in Plateau Region

目的:探讨血浆降钙素基因相关肽(CGRP)和内皮素(ET)水平变化与高原地区子前期患者发病的关系。方法:采用放射免疫法对高原地区重度子前期患者31例和正常晚孕妇女30例,分别于产前及产后1周进行血浆CGRP和ET水平测定。结果:产前重度子前期患者血浆CGRP含量(71.71±3.75 ng/L)明显低于正常晚孕妇女(110.51±7.55 ng/L)(P<0.01),而血浆ET含量(68.96±11.27 ng/L)明显高于正常晚孕妇女(44.70±4.46 ng/L)(P<0.01)。与正常产妇比较,产后1周时子前期患者病情明显缓解,其血浆CGRP(101.21±7.46 ng/L)上升(P<0.01),血浆ET(51.89±7.87 ng/L)下降,接近正常产后水平(P>0.05)。结论:血浆CGRP和ET水平变化是反映高原地区重度子前期患者发病及衡量病情的重要因素。

Objective： To study the change of plasma calcitonin gene-related peptide （CGRP） and endothelin （ET） concentrations and relationship with incidence of preeclampsia in plateau region, Methods：31 patients with severe preeclampsia were compared with 30 normal late pregnant woman in plateau region,the plasma CGRP and ET levels were determined before and one week after delivery by radioimmunoassay. Results： The plasma CGRP level （71.71 ± 3.75 ng/L） was significantly lower in patients with severe preeclampsia than that （ 110.51 ± 7.55 ng/L） of control group （ P 〈 0.01 ） ; but ET level （68.96 ± 11.27 ng/L） was significantly higher than that （44.70 ± 4.46 ng/L） of control group （ P 〈 0.01 ）. The patients＇ conditions with preeclampsia were significantly relieved within one week after delivery, Compared to the control group, their parameters changed remarkably, plasma CGRP level increased （ 101.21 ± 7.46 ng/L） （ P 〈 0.01 ） and ET level decreased to normality （51.89 ± 7.87 ng/L） （ P 〉 0.05）. Conclusions： Levels of plasma CGRP and ET are important to reflect onset of patients with severe preeclampsia and to evaluate patients＇ condition in plateau region.