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线粒体蛋白Smac/DIABLO与细胞凋亡 被引量：1

Mitochondria Protein Smac/DIABLO and Cell Apoptosis
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摘要 第二个线粒体衍生的半胱氨酸蛋白酶激活剂(Smac/DIABLO)是近年来新发现的一种线粒体蛋白,在正常细胞内Smac定位于线粒体.受到凋亡刺激时,Smac蛋白的线粒体定位信号肽被切除,能够从线粒体释放到胞质,与凋亡抑制蛋白(IAP)分子特异性结合,解除凋亡抑制因子对半胱氨酸蛋白酶(caspase)的阻碍作用,激活各级caspase引起级联反应,从而促进凋亡发生.综述了Smac/DIABLO蛋白的结构和功能、参与细胞凋亡的机制及最新的研究进展,最后提出了研究中存在的一些争议及可能的研究趋势. Smac/Diablo is a recently identified mitochondria protein. After apoptotic stimuli, it binds the Inhibitor of Apoptosis （IAP） family of proteins, allowing caspase activation and cell death. The structure and function of Smac/Diablo, as well as its role in the mechanism of cell apoptosis are summarized. Some disputes and trends in the process of research are given.
作者 李静 刘全宏
机构地区 陕西师范大学生命科学学院
出处 《西安文理学院学报（自然科学版）》 2006年第4期5-10,共6页 Journal of Xi’an University(Natural Science Edition)
基金 国家自然科学基金资助项目(39870240 30270383)
关键词 SMAC/DIABLO IAP 凋亡 Smac/DIABLO IAPs apoptosis
分类号 Q255 [生物学—细胞生物学]
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参考文献31

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二级参考文献11

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西安文理学院学报（自然科学版）
2006年 第4期

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