检测尿GPDA对急性肾炎恢复期的判断作用

Clinical significance of detecting urine glycyl-proline dipeptidyl aminopeptidase at convalescence of acute glomerulonephritis

目的探讨尿甘氨酰脯氨酸二肽氨基肽酶(GPDA)检测在急性肾炎恢复期的临床应用价值。方法选择急性肾炎恢复期患者41例,正常人对照组30名,采用连续监测法,分别对其尿中GPDA活性进行测定并与其他反映早期肾损害的指标N-乙酰β-D氨基葡萄糖苷酶(NAG)和尿微量白蛋白(UMA)相比较。结果急性肾炎恢复期患者尿液GPDA、NAG及UMA水平均显著高于正常人对照组的水平(P< 0．05)。尿GPDA与NAG和UMA呈显著正相关(r=0．719,r=0．626,P<0．01)。结论尿液GPDA测定对急性肾炎临床治愈期患者肾功能恢复情况的判断具有重要的临床应用价值。

Objective 15 study the clinical significance of detecting urine glycyl-proline dipeptidyl aminopeptidase （GPDA） at convalescence of acute glomerulonephritis. Methods Urine GPDA activities in 41 cured phase of acute glomerulonephritis patients and 30 normal subjects were measured by continuous monitoring method and compared with other indicesas N-acetyl-β-D-glucosaminidase （NAG） and urine minimal albumen（UMA） reflecting early kidney injury.Results The urine GPDA levels in cured phase of acute glomerulonephritis patients were higher obviously than those in normal subjects （P〈0.05）, Positive correlations were shown between GPDA and NAG, UMA（r=0.719,r=0.626, P〈0.01）.Conclusioa The value of urine GPDA is an useful index for judging resterativeness at convalescence of acute glomerulonephritis.