卡托普利对家兔急性心肌梗塞早期血小板活化及纤溶活性的影响

ffect of Captopril on Platelet Activation and Fibrinolytic Activity in the Early Phase of Acute Myocardial Infarction in Rabbit

本研究观察了家兔急性心肌梗塞（ＡＭＩ）早期血浆血小板α－颗粒膜蛋白（ＧＭＰ－１４０）、血栓素Ｂ＿２（ＴＸＢ＿２）、组织型纤溶酶原激活剂（ｔ－ｐＡ）及其抑制物（ＰＡＬ－１）水平的变化及卡托普利干预的影响。结果显示，ＡＭＩ早期血浆ＧＭＰ－１４０浓度、ＴＸＢ＿２浓度、ｔ－ｐＡ含量、ＰＡＩ－１活性均明显升高，ｔ－ＰＡ活性显著降低；相关分析表明，血浆ＧＭＰ－１４０浓度与ＰＡＩ－１活性显著正相关。卡托普利干预后，血浆ＧＭＰ－１４０浓度、ＴＸＢ＿２浓度、ｔ－ＰＡ含量、ＰＡＩ－１活性均明显降低，而ｔ－ＰＡ活性显著增高，心肌梗塞范围缩小。提示，ＡＭＩ早期纤溶活性降低与血小板活化有关；卡托普利抑制ＡＭＩ早期血小板活化，改善纤溶活性，可能是其治疗ＡＭＩ作用机制之一。

hanges of plasma levels of alpha-granule membrane protein 1 40(GMP-140),thromboxaneB_2(TXB_2),tissue-type plasminogen activator(t-pA ),plasminogen activator inhibitor(PAI-1)andthe effect of captopril were studied in the early phase of experimental acute myocardial infarction(AMI)in rabbits by ligation of the left ventricular coronary artery.24 rabbits were equally divid-ed into 3 groups,namely sham operation,AMl and AMI+Captopril.The results showed that inthe early phase of AMI plasma levels of GMP-140,TXB2,t-pA antigen,PAI-1 activity were sig-nificantly elevated,t-pA activity was significantly decreased ,and plasma levels of GMP-140 werecorrelated significantly with plasma PAI-1 activity.Captopril administration significantly de-creased plasma GMP-140, TXB2,t-PA antigen,PAL-1 activity,increased plasma t-PA activity,and reduced myocardial infarct size. The result suggest that decreased fibrinolytic activity in theearly phase of AM I has relation with activation of platelet,and also that captopril can inhibitplatelet activation,improve fibrinolytic activity ,and thus is beneficial to AMI.