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Na^+/H^+交换在急性呼吸性酸中毒脑脊液酸碱调节中的作用 被引量:3

Role of Na ̄+/H ̄+ Exchange on Cerebrospinal Fluid Acid-base Regulation in Acute Respiratory Acidosis
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摘要 犬急性呼吸性酸中毒(ARA)模型通过吸入8%~10%CO_2气体产生。在ARA6h期间,对照组和氨苯蝶啶组PaCO_2、[HCO_3]s和脑脊液(CSF)PCO_2分别升高约5.0kPa、4.0mmol/L和5.8kPa,两组之间比较无显著差异。然而,两组的改变却相差非常显著(p<0.01),对照组平均升高8.5mmol/L,氨苯喋啶组平均升高4.5mmol/L,两组的差不能用CSF其它离子浓度改变所解释。结果表明ARA时,Na ̄+/H ̄+交换可能在调节中有一定作用。 cute respiratory acidosis in dogs were induced by 8%~10%CO_2 breathing during 6hours,During Acute respiratory acidosis in 6 hours, arterial PCO_2,plasma and cere-brospinal fluid (CSF)PCO_2 rose respectively by about 5.0kPa,4. 0mmol/L and 5.8kPa in bothgroups (p>0.05).However,changes in CSF were significantly different between the twogroups(p<0.01);in the control group,mean rose by 8.5mmol/L in 6 hours afterinduction of acute respiratory acidosis. In the triamterene group,the rise was only 4.5mmol/LThe differences in could not be ascribed to differences in CSF other ion concertra-tion, We conclude that Na+-H+ exchange may play a role in the regulation of dur-ing acute respiratory acidosis in dogs.
出处 《基础医学与临床》 CSCD 1996年第4期301-304,共4页 Basic and Clinical Medicine
关键词 脑脊液 酸碱调节 呼吸性 酸中毒 脑脊液 Cerebrospinal fluid Acid-base regulation Triamterene Respiratory acidosis
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