氨基酸酯取代聚膦腈的分子结构和性能关系的研究——(Ⅰ)合成与表征

Study on the Relationship Between Structure and Properties of Poly[(amino acid ester)phosphazene](Ⅰ): Synthesis and Characterization

从分子设计的角度出发,以甘氨酸乙酯、丙氨酸乙酯和苯丙氨酸乙酯为亲核试剂,成功地制备了一系列氨基酸酯单取代和混合取代的聚膦腈。研究了取代反应条件及亲核试剂的添加顺序对聚合物合成及结构的影响,取代反应过程中反应温度、反应时间对氨基酸酯取代度的影响,以及亲核试剂的添加顺序对聚合物合成及结构的影响,其结果为控制合成该类可降解聚合物提供了更多依据。

A series of amino acid ester substituted and mixed-substituted polyphosphazenes have been prepared by nucleophilic substitution of poly（dichlorophosphazene） with various amino acid esters. ^1H-NMR and ^31P-NMR analysis showed the expected polyphosphazenes were successfully synthesized with high yields. By varying the reaction conditions, the influence factors on the amino acid ethyl ester＇s degree of substitution were investigated and polymers with the higher amino acid ethyl ester＇s degree of substitution were obtained under optimized reaction condition. Moreover, during synthesizing cosubstituent polyphosphazenes, it is found that the addition sequence of two amino acid ethyl esters is an important factor deciding the structure of resultant polymer. And the results of this work can be valuable and provide a primary reference for synthesizing poly[（amino acid ester）phosphazenes].