孕期微波辐射暴露对子代小鼠的遗传毒性

Effects of Microwave Radiation Exposure of Pregnant Mice on Offspring

目的探讨孕期接受微波辐射对仔鼠遗传学方面的影响。方法选择健康昆明小鼠45只(雌鼠30只,雄鼠15只),按雌∶雄为2∶1合笼。将妊娠的雌鼠随机分为对照组、低剂量组和高剂量组,分别采用0、570、1400μW/cm2的模拟辐射源对孕鼠进行全身辐射,进行其子代骨髓细胞染色体畸变(chromosomeaberration,CA)试验、姐妹染色单体交换(sisterchromatidexchange,SCE)试验和嗜多染红细胞微核试验。结果高剂量组SCE的频率(2.64±0.21)高于对照组(1.49±0.23),差异有统计学意义(P<0.05)。染色体畸变率和微核率有随剂量升高而上升的趋势。但高剂量组、低剂量组、对照组间染色体畸变率和微核率差异均无统计学意义(P>0.05)。结论孕期微波辐射暴露对仔鼠的遗传物质具有一定的影响。目的探讨孕期接受微波辐射对仔鼠遗传学方面的影响。方法选择健康昆明小鼠45只(雌鼠30只,雄鼠15只),按雌∶雄为2∶1合笼。将妊娠的雌鼠随机分为对照组、低剂量组和高剂量组,分别采用0、570、1400μW/cm2的模拟辐射源对孕鼠进行全身辐射,进行其子代骨髓细胞染色体畸变(chromosomeaberration,CA)试验、姐妹染色单体交换(sisterchromatidexchange,SCE)试验和嗜多染红细胞微核试验。结果高剂量组SCE的频率(2.64±0.21)高于对照组(1.49±0.23),差异有统计学意义(P<0.05)。染色体畸变率和微核率有随剂量升高而上升的趋势。但高剂量组、低剂量组、对照组间染色体畸变率和微核率差异均无统计学意义(P>0.05)。结论孕期微波辐射暴露对仔鼠的遗传物质具有一定的影响。

Objective To study the relationship between microwave radiation exposure during pregnancy and the offspring health. Methods The pregnant Kunming mice were divided into 3 groups and exposed to microwave radiation of 0, 570 and 1 400 μW/cm^2 respectively. The bone marrow ceils of the offspring were collected for the determination of chromosome aberration （CA）, sister chromatid exchange （SCE） and micronucleus frequency （MNF）. Results SCE showed a significant change in high intensity group, as for CA and MNF, no significant change was seen compared with the control. Conclusion Microwave radiation exposure during vregnanev may induce germ plasm damages in the offspring.