帕珠沙星对呼吸、泌尿系统感染的细菌体外抗菌活性研究

Antibacterial Activity of Pazufloxacin in vitro Against Bacteria Isolated from Patients with Respiratory and Urinary Tract Infection

目的以左氧氟沙星、环丙沙星、头孢呋辛、头孢噻肟为对照,研究帕珠沙星对治疗呼吸、泌尿系统感染细菌的体外抗菌活性,为临床提供用药依据。方法采用全自动细菌鉴定仪VITEK系统对感染的细菌作鉴定,用药敏卡MIC法与KB纸片法同时做药敏试验。结果对大多数革兰阴性菌帕珠沙星的敏感性与左氧氟沙星、头孢噻肟等基本一致,但帕珠沙星对假单胞菌属和不动杆菌属的敏感性要明显高于其他4种抗菌药物;而对革兰阳性球菌,其中尤其对链球菌属帕珠沙星的敏感性明显低于头孢类抗菌药物,且与其他喹诺酮类药物相比无优势。结论帕珠沙星对呼吸、泌尿系统感染的革兰阴性菌体外抗菌活性较强,尤其对泌尿系统的抗菌作用更好,具有优异的广谱性及较强的抗菌活性,但对革兰阳性球菌的抗菌活性还有待提高。

OBJECTIVE To study the antibacterial activity of pazufloxacin in vitro against bacteria isolated from patients with respiratory and urinary tract infection, compared with levofloxacin, ciprofloxacin, cefuroxime and cefotaxime to provide guideline for clinical application. METHODS The infected bacteria were identified by the fully automatic VITEK system. The susceptibility test was determined by MIC method and K-B disk diffusion method respectively. RESULTS The sensitivity of most Gram-negative bacteria to pazufloxacin was basically the same to levofloxacin, cefotaxime, etc. However, the sensitivity of Pseudomonas and Acinetobacter to pazufloxacin was higher than to other four antibiotics; the sensitivity of Gram-positive cocci, particularly Streptococcus to pazufloxacin was obviously lower than cephalosporins and no better than other quinolones. CONCLUSIONS The antibacterial activity of pazufloxacin in vitro against the bacteria isolated from patients with respiratory and urinary tract infection is comparatively strong, especially in the urinary system. Pazufloxacin has an excellent broadspectrum and strong antibacterial activity. However, the antibacterial activity against Gram-positive cocci is expected to promote.