宁夏枸杞多糖对CCl_4损伤大鼠肝脏的保护作用

PREVENTIVE EFFECT OF LYCIUM BARBARUM POLYSACCHARIDE ON LIVER INJURY INDUCED BY TETRACHLOROMETHANE

以ＣＣｌ＿４诱发大鼠肝脏脂质过氧化为自由基损伤模型，观察枸杞多糖（ｌｙｃｉｕｍ ｂａｒｂａｒｕｍｐｃｌｙｓａｃｃｈａｒｉｄｏ，ＬＢＰ）不同剂量（２５ｍｇ／１００ｇＢＷ·ｄ－１；５０ｍｇ／１００ｇＢｗ·ｄ－１）对鼠肝的保护作用。结果低剂量组能明显降低肝中丙二醛（ＭＤＡ）及甘油三脂（ＴＧ）（Ｐ＜０．０１，Ｐ＜０．０５）；两剂量组均能明显升高肝中超氧化物歧化酶（ＳＯＤ）活性（Ｐ＜０．００１）。提示ＬＢＰ对鼠肝自由基损伤有保护作用。高剂量组对ＭＤＡ及ＴＧ降低作用不明显，ＬＢＰ减轻脂质过氧化作用可能存在最佳剂量范围。

he preventivc cffcct of two doses of Lycium barbarum Polysaccharide(50mg/100g BW, 25mg/100g Bw)against lipid peroxidation in jury induced by CCl4 in wistar ratsliver were observed.In the livers of rats trcatcd with low doses of Lycium barbarumpolysaccharide(LBP),the MDA and TG content were rrduccd(P<0. 01,P<0. 05);inbothlow and high docs groups thc activity of SOD was high(P<0.001),indicating thatLBP could protcct liver from thc frcc radiccal injury and there exists an effective dosesrange of LBP。