摘要
目的:研究局部脑血流量定量测定在痴呆病人诊断和疗效监测中的临床价值。材料和方法:55例痴呆病人应用133Xe吸入法和脑血流仪测定大脑半球和小脑-脑干(左右各分14区)的平均和局部脑血流量(mCBF和rCBF),并转换为rCBF彩色地形图。55例中19例治疗前后进行了检测,部分病例与SPECT、X-CT和EEG比较。结果:55例病人见左右大脑mCBF降低,以多发性梗塞性痴呆(MID)和混合型(AM)较早老性痴呆(AD)为低,mCBF降低>1.5SD以上者占72.7%(左右侧),rCBF以顶叶降低最多,其次为枕、额和颞叶。19例治疗前mCBF降低>1.5SD以上者占89.5%(左右侧);治疗后mCBF降低者占73.7%(左侧)和57.9%(右侧)。rCBF以额、顶叶好转最为明显;其中以AM型明显,其次为MID和AD型。总好转率为31.5%,个别病例好转十分明显。结论:133XerCBF定量测定对痴呆症的诊断和疗效监测是较好的定量指标,值得推广运用。
Purpose:To study the diagnostic use and therapeutic monitoring of the 133Xe mean and regional cerebral bloodnow (mCBFand rCBF)determinaton in Alzheimer's Diseases(AD).Materials and Methods:The mCBF and rCBF of 19 cases of cerebral hemispheres and cerebellummeddulla in 55 cases of AD measured by 133Xe iuhalation and cerebragraphy were obtained together with their rCBF color images.Simultaneously also measured the mCBFand rCBF before and after traditional medicine therapy.Part of the cases compared with SPE CT,X-CT and EEG,Results:Right and left cerabral mCBF decreased in 55 cases by the order of MID.AM and AD. mCBF decreased over1.5SD about 72.7% (left and right),the rCBF increased more in parietal lobes,than the occiptal frontal and temperal lobes.After therapy mCBF decreased more in AM than MID and AD.The overall improved rate was 31.5%,and very significant in 3 individual cases.Conclusion:133Xe rCBF quantitative determination was a quite good parameter for the diagnosis and therapeutic monitoring in Alzhimer's diseases.And wide application was suggested.
出处
《中国医学计算机成像杂志》
CSCD
1996年第2期120-123,共4页
Chinese Computed Medical Imaging
关键词
痴呆
局部脑血流量
氙133
脑血流量
Alzheimer's diseases Regional cerebral blood flow  ̄(133)Xenon