晚期正常妊娠及妊高征患者血清一氧化氮水平及其意义

The serum nitric oxide level and its significance in the women with uncomplicated pregnancies and PIH.

应用 Greiss 反应测定35例育龄非孕妇女、32例正常晚期妊娠妇女及32例妊高征患者的血清一氧化氮含量,以探讨一氧化氮在正常妊娠及妊高征发病机理中的作用。结果:正常晚期妊娠妇女血清一氧化氮含量明显高于育龄非孕妇女(P<0.001),而妊高征患者的血清一氧化氮含量明显低于正常孕妇(P<0.001)。表明:妊娠期一氧化氮合成增加对维持正常妊娠具有重要意义;妊高征的发生可能与妊娠期一氧化氮合成减少有关。

To measure the serum concentration of nitric oxide of maternal circulation and determine whether the nitric oxide level is decreased in patients with PIH.Design:35 nonpregnant women,32 normal pregnant women and 32 women with PIH were stud- ied.Maternal venous blood samples were collected from all of them.Serum nitric oxide concentrations were determined with the greiss reaction by measuring oxidation products of nitric oxide.Results:Serum ni- tric oxide concentrations in women with uncomplicat- ed pregnancies were significantly higher than these in nonpregnant women(P<00.001),while serum nitric oxide concentrations in women with PIH were signifi- cantly lower than those in women with uncomplicated pregnancies.Conelusion:The increasing of nitric oxide synthesis during pregnancy is important to maintain the normal pregnancy and the genesis of PIH may he associated with the decreasing of nitric oxide synthesis during pregnancy.