醋己氨酸锌胶囊的相对生物利用度研究

RELATIVE BIOAVAILABILITY OF ZINC ACEXAMATE CAPSULES

醋己氨酸锌是一种新型治疗消化道溃疡的药物，本文采用原子吸收光谱法，研究了１０名男性健康志愿者随机口服国产的醋己氨酸锌胶囊剂与国外产品的相对生物利度，结果表明，国产醋己氨酸锌胶囊剂的吸收相较国外产品稍快，ｔ１／２ｋａ分别为（０．８９５±０．４０４）ｈ和（０．９２３±０．１８９）ｈ，而两者的消除相基本一致，ｔ１／２ｋａ分别为（１．６３２±０．５１９）ｈ和（１．３８３±０．２２７）ｈ，其相对生物利用度为８８．８２％。

An atomic absorption photometric method was developed for the quantitative determination of Zinc Acexamate(ZAC) serum level in the healthy male volunteers.The relative bioavailability was studied in the volunteers after a single oral dose of ZAC capsules made in China and imported.The absorbtion of domestic ZAC was faster than that of the imported,and the elimination made no significant difference.The relative bioavailability was 88.82%