β─环糊精与氯霉素在水溶液中的包合作用

The Inclusion Action between Chloramphenicol and β Cyclodextrin

研究β－环糊精（β－ｃｙｃｌｏｄｅｘｔｒｉｎ，β－ＣＤ）与氯霉素（ｃｈｌｏｒａｍｐｈｅｎｉｃｏｌ）在水溶液中的包合反应。测定紫外吸收光谱变化值（ΔＡ），用连续递变法测定包合物组成的摩尔比。实验证明，氯霉素在β－ＣＤ水溶液中的溶解度曲线呈ＡＬ型，包合物组成摩尔比为１∶１。温度升高，氯霉素－β－ＣＤ包合物的形成常数Ｋｆ减少，包合物生成能（ΔＧ）增大，反应热（ΔＨ）为－６０．５３ＫＪ／ｍｏｌ。包合过程为放热过程。

The inclusion reaction of chloramphenicol and β cyclodextrin in aqueous solution was studied. The change (ΔA) of ultraviolet spectrum was determined. The composition ratio of the inclusion complex between chloramphenicol and β CD was obtained by the continueous variation method. The solubility diagram of chloramphenicol in aqueous solution of β CD was of A L type,and the composition ratio of the inclusion complex was 1∶1. With the temperature increasing,the formation constant value of the inclusion complex decreased.The reaction heat was -60.53 KJ/mol. The inclusion reaction is an exothermic one.