进展期胃癌的淋巴结转移特点及其临床意义

Metastasis rates of lymph nodes and distribution in advanced gastric cancer and its clinical significance

目的探讨进展期胃癌的淋巴结转移特点及临床意义。方法对2002年4月至2003年7月期间进行胃癌根治淋巴结清扫手术的91例患者的手术切除标本进行解剖,收集切除的淋巴结,逐枚进行病理组织学和免疫组织化学检查,判断淋巴结是否转移并计算淋巴结转移率。分析淋巴结转移率与肿瘤大小、TNM分期、Borrmann分型、肿瘤部位和淋巴结清扫范围等方面的关系。结果91例胃癌患者中淋巴结转移阳性63例(69．2%)。共收获3149枚淋巴结,平均每例34．6枚。肿瘤直径小于3 cm者淋巴结转移率较3 cm以上者低(P＜0．05)。TNM分期中Ⅲα和Ⅳ期患者淋巴结转移率均为100%,其转移度在30．3%～58．4%之间,较Ⅰ、Ⅱ期者高(P＜0．001)；Borrmann分型中Ⅲ型病例的淋巴结转移率(79．6%)较其他型患者高,而Ⅳ型患者淋巴结转移度(35．3%)最高(P＜0．05)。施行D_3淋巴结清扫手术患者的淋巴结转移率和转移度(88．2%、38．0%)均高于D_1、D_2术患者(P＜0．05)。17例(18．7%)患者常规病理检查发现有183枚淋巴结微转移,肿瘤各部位与淋巴结微转移的关系差异无统计学意义(P＞0．05)。近端胃癌淋巴结转移主要在第1、2、3、5、7、8、9、12、13和16组,以8组转移度为最高(68．1%)；中部胃癌淋巴结转移主要在第1、3、7、12、13和16组,其中最高转移度为第3组(47．6%)；远侧胃癌淋巴结转移主要见于1、2、3、5、6、12、13和16组,其中第16组转移度为最高(83．3%)。结论淋巴结转移率和转移度与胃癌的恶性程度密切相关,因此D_3淋巴结清扫手术对某些进展期胃癌患者值得考虑使用。

Objective To investigate the characteristics of lymph node metastases in advanced gastric cancer and its clinical significance. Methods From April 2002 to July 2003, we studied 91 patients with advanced gastric cancer who underwent radical gastrectomy and lymphadenectomy from which specimens were obtained during surgery. Then, collection of dissected lymph node, histopathological and immunohistolagical studies were performed to detect the lymph node metastasis rates and calculation. In addition, to analyze the relationship between lymph node metastasis rates and tumor diameters, TNM classification, Borrmarm analysis, tumor localization and the extent of lymph node resection. Results Among 91 patients with advanced gastric cancer, lymph node metastases were found in 63 patients （69.2%） with a total collection of 3149 lymph nodes and an average of 34.6 lymph nodes collected per patient. Lymph node metastasis rate was lower in tumor 〈 3 cm than that in tumor 〉 3 cm. About TNM classification, lymph node metastases in advanced gastric cancer among patients in stage Ⅲa and stage Ⅳ was 100%, with the lymph node metastasis rates varying from 30.3% to 58.4%, which were significantly higher than that among patients in stage Ⅰ and Ⅱ （P 〈 0.001）. About Borrmann classification, lymph nodes metastasis in advanced gastric cancer among patients in Borrmann type Ⅲ （79.6%） was higher than other Borrmarm types, while in Borrmann type Ⅳ with the highest lymph node metastasis rate of 35.3% （P 〈 0.05）. Patients undergone lymph node dissection D3 had higher lymph node metastases among patients and higher lymph node metastasis rate （88.2%, 38.0%） than patients in the D1 and D2（P 〈 0.05）. Among 91 patients, 17 patients was found with mierometastasis （18.7%） from which 183 lymph nodes was collected, but no statistically significant difference between tumor location and micrometastasis was found （P 〉 0.05）. For tumor localization, lymph node metastases in proximal gastric cancer were more shown in station 1, 2, 3, 5, 7, 8, 9, 12, 13 and 16, with the highest metastasis rate in station 8 （68.1%）. Lymph node metastases in middle gastric cancer were more shown in station 1, 3, 7, 12, 13 and 16, with the highest metastasis rate in station 3 （47.6%）. Lymph node metastases in distal gastric cancer were more shown in station 1, 2, 3, 5, 6, 12, 13, and 16, with the highest metastasis rate in station 16 （83.3%）. Conclusion Metastasis among patients and lymph node metastasis rates are significantly correlated with the severity of gastric malignancy and they may be valuable guideline to evaluate the extension of lymph nodes dissection in gastric cancer.