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N-乙酰半胱氨酸对小鼠巨噬细胞Toll样受体2/4基因表达的影响 被引量：2

Effect of NAC on LPS-induced toll-like receptor 2 and 4 expressions in murine macrophages
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摘要 Toll样受体（TLRs）是病原微生物跨膜信号转导的重要受体，其中TLR2是一种具有广泛识别能力的“模式”受体，而TLR4在炎症反应中的作用尤为显著，体外观察证实它是细菌内毒素的识别与信号转导过程中的主要受体。N-乙酰半胱氨酸（NAC）可进入体内合成还原性谷胱甘肽，改变细胞氧化还原平衡状态。现采用NAC调整巨噬细胞内活性氧（ROS）水平，观察其对脂多糖（LPS）所致小鼠巨噬细胞TLR2／4基因表达的影响。
作者 金鑫 吴河水 田元 张景辉 王春友
机构地区 华中科技大学附属协和医院胰腺外科中心
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2006年第11期852-854,共3页 Chinese Journal of Hepatology
基金 国家自然科学基金(30200272)
关键词 乙酰半胱氨酸 脂多糖类 TOLL样受体 Acetylcysteine Lipopolysaccharides Toll-like receptor
分类号 R346 [医药卫生—基础医学]
  • 相关文献

参考文献10

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二级参考文献17

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共引文献21

同被引文献11

  • 1李舒丹,厉有名,虞朝辉.大鼠慢性酒精性肝损伤观察[J].中国公共卫生,2004,20(2):195-196. 被引量：8
  • 2张宇,陈韶华,张幸国,任国平,萨小婴,虞朝辉,厉有名.茶多酚治疗慢性酒精性肝损伤的实验研究[J].中华肝脏病杂志,2005,13(2):125-127. 被引量：15
  • 3赵初环,卢中秋,李惠萍,吴斌,李景荣,胡国新.大鼠酒精性肝病模型的建立[J].浙江临床医学,2007,9(4):435-436. 被引量：16
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  • 9杨明杰,周建嫦,黄俊明,杨杏芬.酒精性肝病发生机制研究进展[J].中国公共卫生,2003,19(3):367-368. 被引量：11
  • 10Resat Ozaras,Veysel Tahan,Seval Aydin,Hafize Uzun,Safiye Kaya,Hakan Senturk.N-acetylcysteine attenuates alcohol-induced oxidative stess in rats[J].World Journal of Gastroenterology,2003,9(4):791-794. 被引量：9

引证文献2

二级引证文献13

中华肝脏病杂志
2006年 第11期

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