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The Role of sICAM-1 Detection in the Diagnosis of Acute Rejection Following Liver Transplantation 被引量:1

The Role of sICAM-1 Detection in the Diagnosis of Acute Rejection Following Liver Transplantation
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摘要 In order to evaluate the applied value of soluble intracellular adhesion molecule-1 (sICAM-l) in acute rejection (AR) following liver transplantation, the expression of sICAM-1 protein was sequentially detected by using ELISA in serum and bile of 43 patients receiving liver transplantation. In AR group, the expression levels of sICAM-1 protein were increased 3 days before and immediately on the establishment of AR diagnosis, and there was significant difference in the expression of bile between AR group and control group (P〈0.01). After reversion of AR with hormone intensive therapy, there was significant difference in the sICAM-1 protein expression of serum and bile between AR group and control group. It was concluded that the sequential detection of sICAM-1 protein level in serum and bile was a reliable and noninvasive method for the early diagnosis of AR after liver transplantation and was valuable to observe the curative effects of anti-AR therapy. In order to evaluate the applied value of soluble intracellular adhesion molecule-1 (sICAM-l) in acute rejection (AR) following liver transplantation, the expression of sICAM-1 protein was sequentially detected by using ELISA in serum and bile of 43 patients receiving liver transplantation. In AR group, the expression levels of sICAM-1 protein were increased 3 days before and immediately on the establishment of AR diagnosis, and there was significant difference in the expression of bile between AR group and control group (P〈0.01). After reversion of AR with hormone intensive therapy, there was significant difference in the sICAM-1 protein expression of serum and bile between AR group and control group. It was concluded that the sequential detection of sICAM-1 protein level in serum and bile was a reliable and noninvasive method for the early diagnosis of AR after liver transplantation and was valuable to observe the curative effects of anti-AR therapy.
出处 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2006年第5期580-582,共3页 华中科技大学学报(医学英德文版)
关键词 orthotopic liver transplantation acute rejection BILE SERUM SICAM-1 orthotopic liver transplantation acute rejection bile serum sICAM-1
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