肺癌脑转移60例临床分析

Clinical analysis on 60 lung cancer patients with brain metastasis

目的:探讨对肺癌脑转移患者行手术、放疗及辅以联合化疗后的疗效比较。方法:对1999年1月～2005年12月间我院收治的经头颅CT和/或MRI检查、手术后病理学证实的肺癌脑转移60例进行回顾性分析。结果:手术+放化疗组、放疗+化疗组的中位生存期分别为12个月、11个月,1年生存率分别为25.0%、21.8%;单纯放疗组、单纯化疗组分别为5个月、6个月,及7.69%、0,差异有统计学意义(P<0.05)。结论:肺癌脑转移采用以放疗为主的综合治疗是一种比较合理的治疗方法,可延长生存期、提高疗效。

Objective： To analyze the effects of surgery,radiotherapy combined with chemotherapy for treating lung cancer patients with brain metastasis.Methods ：60 lung cancer patients with brain metastasis certified by brain CT and/or MRI ,pathology were retrospectively analyzed between January,1999 and December,2005. Results ：The median survival time was 12 months for surgery combined with radiotherapy and chemotherapy group and 11 month for radiotherapy combined with chemotherapy group, respectively. The 1-year survival rate was 25.0% and 21.8% respectively.The median survival time was 5 months in pure radiotherapy group and 6 months in pure chemotherapy group, The 1-year survival rate was 7.69% in pure radiotherapy group and 0% in pure chemotherapy group. There was statistically significant difference （ P 〈 0.05 ） between them. Conclusion ：The colligational therapy basing on radiotherapy is more effective , which could elongate the survival time and improve the effects.