颞下颌关节上腔灌洗前后关节液一氧化氮含量检测及临床研究

Measurement of NO content in synovia of the upper temporomandibular joint spaces before and after lavage

目的研究颞下颌关节上腔灌洗前后关节液中一氧化氮含量变化。方法采用改良荧光分光光度法测定77例颞下颌关节紊乱病患者关节上腔灌洗前后关节液中一氧化氮水平和10例健康志愿者作对照。临床指标选择开口度、下颌前伸、侧向运动和疼痛程度。结果10例志愿者有一例检测出NO含量(0.17μmol/L)。颞下颌关节紊乱病患者治疗前关节液NO含量(0.667μmol/L^11.111μmol/L)治疗后关节液NO含量比治疗前显著下降(P<0.05)。结论一氧化氮与颞下颌关节紊乱病病理过程有关,关节上腔灌洗治疗颞下颌关节紊乱病疗效显著。

Objective To study the change of NO content in synovia of temporomandibular joint upper cavity before and after lavage. Methods NO content in temporomandibular joint upper cavity of 77 patients with temporomandibular disorders （TMD） were measured with improved fluorometric assay, which were compared with those of 10 normal volunteers, Mouth opening protrusion, left or right lateral jaw movement and degree of pain was selected for clinical index, Results Small amount of NO content was detected in only 1 out of ten volunteers, NO content in synovia of patients with TMD decreased remarkably after treatment than that before treatment （ P 〈 0,05）, Conclusion NO is relevant to pathological change of TMD. therapeutic effect of TMD by lavaging temporomandibular upper cavity is obvious.